Cryo-electron tomography (cryo-ET) is a technique enabling the visualization of frozen hydrated biological samples intact from harmful preparation process. Cryo-ET uses an electron microscope to record a series of 2D projection images acquired by tilting a biological sample held at cryogenic temperature. Using computational methods, the 3D images can be aligned and combined mathematically to generate a 3D (tomographic) reconstruction of the sample. A more complete understanding of the particle morphology is accessible by extracting individual slices in different orientations. The 3D volume can also be examined to resolve any ambiguities of the 2D images. Our cryo-ET services lead the global market with unique advantages:
3D structure reconstruction at 2-5 Ã… resolution
Visualization of intracellular, undisturbed organization of macromolecules
State-of-the-art instrument
Versatile data analysis, including 2D suitability and averaging, and 3D reconstruction from existing data sets, and 3D structure refinement